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The IGF-1 Trade-Off: Performance vs. Longevity

FoundMyFitness1 HN recommenders · 2014–2022
517K views · explainer · evergreen · Uploaded 2013-09-04

A short FoundMyFitness explainer on the trade-off between growth hormone/IGF-1 and longevity. Higher IGF-1 helps muscle and cognition, while lower levels are linked to longer lifespan and stress resistance.

Linked in discussions of diet, aging and cancer as a quick summary of how IGF-1 and mTOR growth signaling cut against longevity.

Fitness, sleep & longevityMedicine & infectious disease

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3 comments from Hacker News

@dpatrick862014 · in “What will it take to run a 2-hour marathon?”

Speaking to your question about "what the long term effects of these drugs are": My wife put together a together a pretty interesting video about the "faustian bargain" which is IGF-1 (used as a proxy measure for growth hormone)... video is replete with examples of the effects of low IGF-1/GH or high IGF-1/GH both in animal models and humans. One of the more interesting points in the video is the fact that people with polymorphisms that make their IGF-1 receptor experience some slight loss of function actually live longer (in general). [VIDEO] The video also links to an article which has a bibliography if you're interested.

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@femiagbabiaka2021 · in “For 2M years, humans ate meat and little else: study”

1. Bigger groups === more and better data. I didn't know anyone growing up who was interested in ketogenic or carnivorous diets, now it's much more common. 2. Huge difference between the diet of a westerner following carnivore and traditional tribal carnivorous diets 3. The Inuits weren't particularly healthy, I'm not sure why their diet matters: [LINK] 4. And most importantly, there's a lot of research showing that high levels of IGF-1 associated with diets high in red meat are not good for longevity: [VIDEO]

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@loudtieblahblah2022 · in “Could cancer cells’ iron addiction be their Achilles heel?”

[LINK] [LINK] Its pretty well know mtor/igf-1 stimulates growth. All growth. This is great for youth. Not so much for aging. [VIDEO]

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