Original Zoloft Commercial

SuperBowlSammy0 HN recommenders · 2019–2025
561K views · other · dated · Uploaded 2009-03-12

A one-minute animated commercial for the antidepressant Zoloft, described as the original that inspired later sequels and parodies.

Mostly cited as a recognizable example of antidepressant advertising in debates about pharmaceutical marketing and the serotonin theory.

Watch on YouTube

4 comments from Hacker News

@doitLP2019 · in “Evidence of a nocebo response following a nationwide antidepressant drug switch”

It’s pervasive, especially in the early days of marketing antidepressants to the general public. Example, probably the most the most recognizable anti-depressant ad ever (at least in the US): [VIDEO] @ 0:20

@banads2020 · in “Medications that change who we are”

>Citation required [VIDEO] >"Depression may be related to an imbalance of natural chemicals between nerve cells in the brain. Prescription Zoloft works to correct this imbalance."

CriticalView on HN
@coding1232022 · in “TikTok videos leave teens thinking they have rare mental disorders (2021)”

The drug industry does the same thing. Has anyone else watched a anti-depression medicine commercial and suddenly felt they are depressed? [VIDEO] I mean watch this and tell me you don't want what they're selling.

CriticalView on HN
@427728272025 · in “The serotonin theory of depression: a systematic review of the evidence (2022)”

> People who having passing familiarity with neuroscience often assume that psychiatric medications work by correcting deficiencies, but this isn't true. They think this because that’s literally what the commercial for Zoloft said. [0] [0] [VIDEO]

CriticalView on HN